For more videos follow us on Instagram:🚀 Grab it instantly — just click the button!
Cushing Syndrome is a clinical condition caused by prolonged exposure to excess glucocorticoids, particularly cortisol. It can result from exogenous steroid use (most common cause) or endogenous overproduction due to adrenal or pituitary disorders.
The endogenous causes include Cushing disease (pituitary ACTH-secreting adenoma), adrenal adenomas or carcinomas, and ectopic ACTH production by tumors such as small cell lung carcinoma. Increased cortisol levels lead to characteristic clinical features including central obesity, moon face, buffalo hump, purple striae, muscle weakness, hypertension, and glucose intolerance.
Diagnosis involves screening tests such as low-dose dexamethasone suppression test, late-night salivary cortisol, and 24-hour urinary free cortisol. High-dose dexamethasone suppression test helps differentiate between pituitary and ectopic causes.
Management depends on the underlying cause. Surgical removal of tumors, reduction of exogenous steroid use, or medical therapy targeting cortisol production may be required.
This high-yield video provide a clear conceptual understanding of pathophysiology, diagnosis, and differentiation—making it essential for exam preparation.
For more posts like this just click on the below topics: